Modafinil was studied with the remedy of stimulant dependence, but the results are combined and inconclusive.[24][251] Modafinil is not a managed material in some international locations, contrary to other medicines, which include bupropion, that is also employed to treat despair and nicotine dependence.[252] The scientific trials that have tested modafinil to be a treatment for stimulant abuse have failed to reveal its efficacy along with the ideal dose and length of modafinil therapy stay unclear, and modafinil just isn't a proposed therapy for stimulant abuse.

Therefore, these opportunity long run applications must be regarded as acquiring “insufficient evidence” right up until way more extra research is carried out — Particularly lengthy-expression scientific experiments in huge samples of human people.

iloperidone boosts amounts of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Iloperidone is really a time-dependent CYP3A inhibitor and should cause greater plasma levels of medicines predominantly eliminated by CYP3A4.

Major pores and skin reactions can take place using this type of medicine. Stop applying this medication and Examine with the health care provider immediately When you have blistering, peeling, or loosening from the skin; red pores and skin lesions; critical acne or pores and skin rash; sores or ulcers about the pores and skin; or fever or chills while you're making use of this medication.

This publish is not a suggestion or endorsement for modafinil. This medication is only FDA-authorised for the treatment method of selected unique healthcare disorders, and may only be taken by prescription and with oversight from a licensed healthcare Skilled.

This medication may perhaps result in accidental overdose and Loss of life if taken by other Grownups, little ones, or Animals. Blend any unused drugs with a material like cat litter or coffee grounds.

modafinil will decrease the extent or impact of diazepam buccal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Robust or moderate CYP3A4 inducers may well maximize price of diazepam elimination; therefore, efficacy of diazepam may very well be decreased.

A similar research also recommended the adolescent brain is particularly sensitive to the effects of stimulants including methylphenidate

Dose adjustments of those medicines together with other medicine that happen to be substrates for CYP2C19 might be important if modafinil is coadministered

A 2020 evaluate reported that modafinil incorporates a modest effect on memory updating, even so the result is small and may not correctly mirror the notion that it is helpful as a cognitive enhancer, as You can find inadequate evidence to assist this kind of claim.[264]

modafinil will decrease the level or outcome website of mavacamten by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.

Modafinil was regarded for that cure of ADHD because of its lower abuse potential than typical psychostimulants[23] like methylphenidate and amphetamines.

Should you be allergic to modafinil; any portion of the medication; or any other prescription drugs, foods, or substances. Inform your medical doctor regarding the allergy and what signals you had.

This individual also expert a intense withdrawal syndrome after halting modafinil use, and claimed many symptoms such as exhaustion, stress and anxiety, and also the loss of a chance to come to feel enjoyment (